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COMPLEMENT C3-C5 CONVERTASES
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DeCS
Descriptor
English
:
Complement C3-C5 Convertases
Descriptor
Spanish
:
Convertasas del Complemento C3-C5
Descriptor
Portuguese
:
Convertases dos Complementos C3-C5
Synonyms
English
:
C3 Convertase
Tree Number:
D12.776.124.486.274.045.387
Definition
English
:
Serine proteases that cleave
COMPLEMENT C3
into
COMPLEMENT C3A
and
COMPLEMENT C3B
, or cleave
COMPLEMENT C5
into
COMPLEMENT C5A
and
COMPLEMENT C5B
. These include the different
forms
of C3/C5 convertases in the classical and the alternative pathways of
COMPLEMENT ACTIVATION
. Both cleavages take place at the C-terminal of an
ARGININE
residue.
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1978)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
50828
Unique Identifier:
D050577
Occurrence in VHL
:
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